Chlorphenamine Maleate 2mg/5ml - Oral Solution - 150ml

Chlorphenamine Maleate 2mg/5ml - Oral Solution - 150ml
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Chlorphenamine Maleate 2mg/5ml - Oral Solution - 150ml

Fast and effective relief from skin allergies and hayfever


 Chlorphenamine Maleate 2mg/5ml - Oral Solution - 150ml

 1. NAME OF THE MEDICINAL PRODUCT

 Chlorphenamine Elixir BP

Rhino-Syrup Allergy

Pollenase Allergy Syrup   

 

2. QUALITATIVE AND QUANTITATIVE COMPOSITION

 Each 5ml contains Chlorphenamine Maleate BP 2.0mg

 

3. PHARMACEUTICAL FORM

 Sugar free syrup in bottles of 150ml

 

4. CLINICAL PARTICULARS

4.1 Therapeutic indications

For the relief of symptoms caused by allergic conditions such as hayfever, allergic rhinitis, perennial rhinitis, vasomotor rhinitis, urticaria and skin rashes, angioneurotic oedema, drug and serum reactions, food allergy, insect bites etc, which are responsive to antihistamines.

 

4.2 Posology and method of administration


Adults and children over 12 years:

 

 

2 spoonfuls (10ml) every 4-6 hours. Daily maximum should be 24mg i.e. 60ml.

Elderly:

 

 

As for adults. Elderly patients are more likely to experience confusional psychosis and other neurological anticholinergic side effects.

Children:

Up to1 year

Not Recommended

 

1-2year

½ spoonful (2.5ml) twice a day

 

2-5 years

½ spoonful (2.5ml) every 4 – 6 hours. Daily maximum should be 6mg i.e.15ml.

 

6-12 years

1 spoonful (5ml) every 4 –6 hours. Daily maximum should be 12mg i.e. 30ml.

4.3 Contraindications

 Chlorphenamine is contraindicated in patients who are hypersensitive to antihistamines or any other ingredients in the syrup.

Chlorphenamine is contraindicated in patients who have had treatment with Monoamine Oxidase Inhibitors (MAOI's) within the last 14 days as the anticholinergic properties of chlorphenamine are intensified by MAOI's.

 

4.4 Special warnings and precautions for use

Chlorphenamine produces anticholinergic effects such as drowsiness, dizziness, blurred vision and psychomotor impairment. This may cause serious problems when the patient is driving or using machinery.

Due to the anticholinergic effect of the drug caution is advised in patients who have epilepsy, raised intra-ocular pressure including glaucoma, prostatic hypertrophy, severe hypertension or cardiovascular disease, bronchitis, bronchiectasis and asthma, hepatic disease and thyrotoxicosis. The neurological anticholinergic effects are more likely in the elderly and children.

The effects of alcohol are likely to be increased.

 

4.5 Interaction with other medicinal products and other forms of interaction

 Alcoholic drinks and certain other central nervous system depressants such as anxiolytics or hypnotics can potentiate the sedative effects of chlorphenamine.

Phenytoin metabolism is inhibited by chlorphenamine and this can cause phenytoin toxicity.

The anticholinergic effects of chlorphenamine are intensified by the use of other anticholinergic drugs such as atropine, tricyclic antidepressants and MAOI's (see contraindications).

 

4.6 Pregnancy and lactation

 Safety in pregnancy has not been established. The use of chlorphenamine in pregnancy should be assessed and only used when the possible benefits outweigh the possible risks to the foetus. Effects on the neonate have been seen when chlorphenamine is used in the third trimester of pregnancy.

There may be some inhibition of lactation by chlorphenamine and some of the drug may be secreted into the breast milk. Therefore the risk to the mother and child should be assessed against the possible benefits of using chlorphenamine when breast feeding.

 

4.7 Effects on ability to drive and use machines

 As with all antihistamines, dizziness and drowsiness may occur. Extreme caution should be advised when driving or operating machinery.

 

4.8 Undesirable effects

 Undesirable effects include sedation, which varies from slight drowsiness to deep sleep.

There have been occasional reports of the following: lassitude, inability to concentrate, blurred vision, hepatitis including jaundice, urinary retention, headaches, dry mouth, dizziness, palpitations, tachycardia, arrhythmias, hypotension, chest tightness, thickening of the bronchial secretions, haemolytic anaemia and other blood dyscrasias, tinnitus, depression, irritability, nightmares, twitching, muscular weakness and incoordination.

Gastrointestinal disturbances have been reported occasionally including, nausea, vomiting, diarrhoea, dyspepsia, abdominal pain and anorexia.

Allergic reactions have been observed and include exfoliative dermatitis, photosensitivity and urticaria.

Paradoxical excitation in children and confusional psychosis in the elderly can occur.

 

4.9 Overdose

 The estimated lethal dose of Chlorphenamine Maleate is 25-50mg per kg bodyweight. Symptoms of overdose include sedation, paradoxical stimulation of the CNS, toxic psychosis, seizures, apnoea, convulsions, anticholinergic effects, dystonic reactions and cardiovascular collapse including arrhythmias.

Treatment should include gastric lavage for massive overdosage or induced emesis using syrup of Ipecacuanha. Following this activated charcoal and cathartics may be administered to minimise absorption.

Symptomatic and supportive measures should be given, with particular attention paid to the cardiac, respiratory, renal and hepatic functions and fluid and electrolyte balance. Hypotension and arrhythmias should be treated vigorously. If convulsions occur sedate with intramuscular paraldehyde, or i.v. diazepam or phenytoin Haemoperfusion may be used in severe cases.

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   This Product is Pharmacy Only [P] and can only be sold under the supervison of a pharmacist.

   You will be required to answer a few basic questions during the checkout process which be reviewed by our pharmacist to ensure that the product is suitable for use.

We are a UK Registered Pharmacy regulated by the GPhC - General Pharmecutical Council.  

PLEASE NOTE: Regulations Prohibit the sale of Pharmacy Only Items Outside of the UK.

Some products marked as pharmacy only items may be subject to age restrictions and may not be suitable for use by everyone.

Always read the label or patient information leafet before taking any medication and if you are unsure speak to your pharmacist.

Delivery Information

Standard Delivery (2 to 5 Working Days) Royal Mail - £2.95*

Orders dispatched using Standard Delivery can take between 2 to 5 working days to arrive.

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*Standard Delivery is FREE for orders over £50.

*For orders of less than £50 there will be a delivery charge of £2.95

Next Day Delivery (Next Working Day)* Starting at £6.95


This is our express delivery option and orders placed before 2pm Monday to Friday will be dispatched on the same day using Royal Mail Next day service, for a guaranteed Next Working Day Delivery.

This service has a tracking number for your parcel so you can follow the progress of your order on its journey to you (see Tracking My Order). You will be required to sign for the parcel so please ensure that you are available at your delivery address between 9am and 5pm on you expected delivery day.          

Delivery Terms and Conditions

If your order is returned to us by Royal Mail because either you have failed to collect or re-arrange delivery for you item or you have provided us with an inaccurate delivery address, a handling charge of £2.95 may be payable.

Next Day Delivery Prices

 Weight (KG) Price
 0.00 - 0.50 £6.95
 0.50 - 1.00 £8.95
 1.00 - 2.00 £12.95
 2.00 - 10.00 £39.95

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