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Otrivine Antistin Eye Drops - 10ml

Otrivine Antistin Eye Drops - 10ml
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Otrivine Antistin Eye Drops - 10ml

Eye drops for the relief of hayfever and allergy.

Otrivine Antistin Eye Drops - 10ml

Main use

Active ingredientManufacturer

Eye allergies

Antazoline sulphate, xylometazoline hydrochloride

Novartis Consumer Health


How does it work?

Otrivine antistin eye drops contain two active ingredients, antazoline and xylometazoline. These medicines work in two different ways to reduce redness and itching of the eyes associated with allergies such as hayfever.

Antazoline is type of medicine called an antihistamine. It works by preventing the actions of histamine, which is a substance produced by the body as part of its defence mechanisms. Histamine is stored in cells called mast cells, in almost all tissues of the body.

When the body reacts to a foreign substance (known as an allergen, eg flower pollen or pet fur), the mast cells stimulated by the allergen release their stores of histamine. The released histamine then binds to its receptors (H-1 receptors), causing a chain reaction that results in allergic symptoms. It causes an increase in blood flow to the area of the allergy, and the release of other chemicals that add to the allergic response. All this results in the symptoms of an allergic reaction.

In hayfever, histamine causes eye symptoms such as inflammation, redness and itching by acting on H-1 receptors in the eyes. Antazoline blocks the H-1 histamine receptors in the eyes, and thus stops these effects of histamine.

Xylometazoline is a type of medicine called a vasoconstrictor. It acts on receptors in the walls of blood vessels in the eyes, causing the blood vessels to narrow. As a result, less blood travels through these vessels to the eye. This helps prevent histamine from entering the eye membrane by restricting the blood flow. It also constricts blood vessels that are dilated as a result of the allergic reaction and so helps reduce redness of the eyes.

One or two drops should be administered into the eye two to three times a day for up to seven days.

What is it used for?

  • Relief from redness and itching of the eyes (allergic conjunctivitis) due to allergies such as hayfever or dust mite allergy.


  • This medicine is for use in the eyes only and must not be taken by mouth.
  • When using the eye drops you should take care to not touch the dropper tip to any surface, or to your eye, in order to avoid contaminating the eye drops.
  • You should not wear soft contact lenses while you are using these eye drops. This is because they contain a preservative called benzalkonium chloride, which can be absorbed by soft contact lenses and cause eye irritation.
  • These eye drops may cause your vision to blur temporarily after you have applied them into your eye. Do not drive or operate machinery until this has worn off.
  • If your symptoms do not improve after two days of using these eye drops you should consult your doctor to make sure you don't have an eye infection that needs treating.
  • These eye drops should not be used for longer than seven consecutive days without consulting your doctor, pharmacist or eye specialist.
  • These eye drops should be discarded four weeks after the bottle is first opened. This is because they could be contaminated with dirt or germs. Write the date of opening on the bottle so you know when to throw them away. Dispose of carefully, preferably by returning to your pharmacy.

Use with caution in

  • Elderly people.
  • Severe disease involving the heart and blood vessels (cardiovascular disease).
  • Irregular heartbeats (arrhythmias).
  • High blood pressure (hypertension).
  • Diabetes.
  • Overactive thyroid gland (hyperthyroidism).
  • Conditions that cause difficulty passing urine, such as an enlarged prostate gland (prostatic hyperplasia).
  • Tumour of the adrenal gland (phaeochromocytoma).
  • Dry eyes.

Seek medical advice before using these eye drops if you suffer from any of these conditions.

Not to be used in

  • Children under 12 years of age.
  • Closed angle glaucoma.
  • People who have taken a monoamine oxidase inhibitor antidepressant (MAOI) in the last 14 days.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine is not recommended for use during pregnancy unless considered essential by your doctor. If you are pregnant you should seek medical advice from your doctor before using this medicine.
  • It is not known if this medicine passes into breast milk. Seek medical advice from your doctor before using this medicine if you are breastfeeding. If the medicine is used the manufacturer recommends you avoid breastfeeding for 48 hours after using the eye drops.

If you are pregnant or breastfeeding and do use these eye drops (only on your doctor's advice), you can minimise the amount absorbed into your bloodstream by pressing on the tear duct while putting in the drops, and for a few minutes after. The tear duct is at the corner of the eye closest to your nose.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Stinging in the eyes after putting in the drops.
  • Temporary blurred vision.
  • Dilated pupils.
  • Increased redness of the eyes.
  • Headache.
  • Drowsiness.
  • Increased heart rate or awareness of your heartbeat (palpitations).
  • Increased blood pressure.
  • Paleness.
  • Feeling sick.
  • Sweating.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

If you are already using any other medicines, including those bought without a prescription and herbal medicines, it is important to check with your pharmacist before using this medicine as well, to ensure that the combination is safe.

The manufacturer states that this medicine should not be used by people who are currently taking a monoamine oxidase inhibitor antidepressant (MAOI), eg phenelzine, isocarboxazid, tranylcypromine or moclobemide, or who have taken one of these medicines in the last 14 days. This is because the combination could cause a dangerous rise in blood pressure.

If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments last.


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   This Product is Pharmacy Only [P] and can only be sold under the supervison of a pharmacist.

   You will be required to answer a few basic questions during the checkout process which be reviewed by our pharmacist to ensure that the product is suitable for use.

We are a UK Registered Pharmacy regulated by the GPhC - General Pharmecutical Council.  

PLEASE NOTE: Regulations Prohibit the sale of Pharmacy Only Items Outside of the UK.

Some products marked as pharmacy only items may be subject to age restrictions and may not be suitable for use by everyone.

Always read the label or patient information leafet before taking any medication and if you are unsure speak to your pharmacist.

Delivery Information

Standard Delivery (2 to 5 Working Days) Royal Mail - £2.95*

Orders dispatched using Standard Delivery can take between 2 to 5 working days to arrive.

Standard Delivery orders are dispatched using the Royal Mail Tracked Service.

This is a priority service with a tracking number so you can follow the progress of you order on its journey to you. You will be required to sign for the parcel so please ensure that you are available at you delivery address between 9am and 5pm on your expected delivery day. (see Tracking My order)

*Standard Delivery is FREE for orders over £50.

*For orders of less than £50 there will be a delivery charge of £2.95

Next Day Delivery (Next Working Day)* Starting at £6.95

This is our express delivery option and orders placed before 2pm Monday to Friday will be dispatched on the same day using Royal Mail Next day service, for a guaranteed Next Working Day Delivery.

This service has a tracking number for your parcel so you can follow the progress of your order on its journey to you (see Tracking My Order). You will be required to sign for the parcel so please ensure that you are available at your delivery address between 9am and 5pm on you expected delivery day.          

Delivery Terms and Conditions

If your order is returned to us by Royal Mail because either you have failed to collect or re-arrange delivery for you item or you have provided us with an inaccurate delivery address, a handling charge of £2.95 may be payable.

Next Day Delivery Prices

 Weight (KG) Price
 0.00 - 0.50 £6.95
 0.50 - 1.00 £8.95
 1.00 - 2.00 £12.95
 2.00 - 10.00 £39.95

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